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76		Thronebreaker: The Witcher Tales (Windows, 2018)
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74		Cthulhu Realms (Windows, 2016)
74		Endhall (Windows, 2018)
72		The Nightmare Cooperative (Windows, 2014)
72		Scrolls (Windows, 2014)
70		Marvel Trading Card Game (Windows, 2007)
65		Rival Books of Aster (Windows, 2017)
65		Overdungeon (Windows, 2018)
65		Grace of Zordan (Windows, 2017)
64		Minion Masters: Forced to Duel (Windows, 2016)
55		Mighty Party (Windows, 2017)
52		Dwarf Tower (Windows, 2014)
48		Solar Settlers (Windows, 2017)
45		The Elder Scrolls: Legends - Heroes of Skyrim (Windows, 2017)
45		Gwent: The Witcher Card Game (Windows, 2017)
45		Shadowhand (Windows, 2017)
45		Forgotten Lore (Windows, 2017)
45		Dead Exit (Windows, 2017)
45		Pathfinder Adventures (Windows, 2017)
44		Artifact (Windows, 2018)
44		Spellweaver (Windows, 2016)
44		Ascension VR (Windows, 2016)
44		Hearthstone: Heroes of WarCraft (Windows, 2014)
43		Cannon Brawl (Windows, 2014)
43		Epic Arena (Windows, 2015)
43		Magic Duels (Windows, 2015)
42		Magic 2015: Duels of the Planeswalkers (Windows, 2014)
42		Magic 2014: Duels of the Planeswalkers (Windows, 2013)
42		Ascension: Deckbuilding Game (Windows, 2014)
42		Shattered Planet (Windows, 2014)
41		Spectromancer (Windows, 2009)
41		Magic: The Gathering (Windows, 1997)
41		Etherlords (Windows, 2001)
40		Ishido (Windows, 2003)
40		Bridge (Windows, 2010)
40		Trump Game (Windows, 2004)
40		MVP Bridge Lite (Windows, 1998)
40		Memory (Windows, 2002)
40		Old Maid (Windows, 2003)
40		Magic: The Gathering - Starter Level (Windows, 2000)
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40		5 Intelligent Strategy Games (DOS, 1991)
40		Magic: The Gathering - Duels of the Planeswalkers 2012 (Windows, 2011)
40		The Games People Play: Gin ∙ Cribbage ∙ Checkers ∙ Backgammon (DOS, 1990)
40		Intelligent Strategy Games 10 (DOS, 1993)
40		Magic: The Gathering - Duels of the Planeswalkers (Windows, 2010)
40		Six Gun Saga (Windows, 2011)
40		Hoyle Children's Collection (Windows, 1996)
40		The Trouble with Robots (Windows, 2012)
40		Guardians of Graxia (Windows, 2010)

Notes: Games similar to Slay the Spire, Games like Slay the Spire, Mega Crit Games, Mega Crit Games, Windows, Strategy, Tactics, Fantasy, Cards, Tiles, Roguelike, Turn-based, Side view, Fixed, Flip-screen, PC, Game Similarities.