67		Sherlock: The Riddle of the Crown Jewels (DOS, 1988)
45		Ballyhoo (DOS, 1986)
45		Moonmist (DOS, 1986)
44		The Hound of Shadow (DOS, 1989)
44		James Bond 007: A View to a Kill (DOS, 1985)
43		Suspect (DOS, 1984)
42		Ooze: Creepy Nites (DOS, 1989)
42		The Witness (DOS, 1983)
41		Hexuma: Das Auge des Kal (DOS, 1992)
40		Curses (DOS, 1995)
40		At Wit's End (Windows, 2002)
40		Guilty Bastards (Windows, 1998)

Notes: Games similar to Sherlock Holmes: The Vatican Cameos, Games like Sherlock Holmes: The Vatican Cameos, Ellicott Creek Software, Ellicott Creek Software, DOS, Adventure, Interactive Fiction, Text Adventure, Detective, Mystery, Belle Époque, PC, Game Similarities.