76		Re-Animator (Comedy, Horror, Sci-Fi, 1985)
74		Weird Science (Comedy, Romance, Sci-Fi, 1985)
64		Bride of Re-Animator (Comedy, Horror, Sci-Fi, 1989)
63		A Boy and His Dog (Comedy, Drama, Sci-Fi, 1975)
61		The Return of the Living Dead (Comedy, Horror, Sci-Fi, 1985)
59		Frankenhooker (Comedy, Horror, Sci-Fi, 1990)
52		PK (Comedy, Drama, Romance, Sci-Fi, 2014)
50		Not of This Earth (Comedy, Horror, Sci-Fi, 1988)
50		Citizen Toxie: The Toxic Avenger IV (Action, Comedy, Fantasy, Sci-Fi, 2000)
49		Dr. Caligari (Comedy, Horror, Sci-Fi, 1989)
49		Repo Men (Action, Crime, Sci-Fi, 2010)
47		Robodoc (Comedy, Sci-Fi, 2009)
47		SOS Coast Guard (Adventure, Romance, Sci-Fi, 1937)
47		The Misadventures of Merlin Jones (Family, Comedy, Sci-Fi, 1964)
47		Idiocracy (Adventure, Comedy, Sci-Fi, 2006)
47		Serena the Sexplorer (Comedy, Sci-Fi, 2013)
47		Britannia Hospital (Comedy, Sci-Fi, 1982)
46		Cheech and Chong's Next Movie (Comedy, Crime, Sci-Fi, 1980)
46		Abbott and Costello Meet Frankenstein (Comedy, Fantasy, Horror, Sci-Fi, 1948)
46		Night of the Creeps (Comedy, Horror, Sci-Fi, 1986)
45		Beyond Re-Animator (Comedy, Crime, Horror, Sci-Fi, 2003)
45		Die You Zombie Bastards! (Comedy, Fantasy, Horror, Sci-Fi, 2005)
44		Creator (Comedy, Romance, Sci-Fi, 1985)
44		Real Genius (Comedy, Romance, Sci-Fi, 1985)
43		My Stepmother Is an Alien (Comedy, Romance, Sci-Fi, 1988)
43		Nice Girls Don't Explode (Comedy, Romance, Sci-Fi, 1987)
43		Remote Control (Comedy, Romance, Sci-Fi, 1988)
43		Humanoids from Atlantis (Action, Comedy, Sci-Fi, 1992)
43		Making Mr. Right (Comedy, Romance, Sci-Fi, 1987)
42		Kamillions (Comedy, Romance, Sci-Fi, 1990)
42		Brainscan (Comedy, Horror, Sci-Fi, 1994)
42		The Hitchhiker's Guide to the Galaxy (Adventure, Comedy, Sci-Fi, 2005)
42		Double Team (Action, Comedy, Sci-Fi, 1997)
42		The Tuxedo (Action, Comedy, Sci-Fi, 2002)
42		Decoys (Comedy, Horror, Sci-Fi, 2004)
42		Frog-g-g! (Sci-Fi, Comedy, Horror, 2004)
42		Top of the Food Chain (Comedy, Horror, Sci-Fi, 1999)
42		Space Station 76 (Comedy, Drama, Sci-Fi, 2014)
41		Chopping Mall (Comedy, Horror, Sci-Fi, 1986)
41		Interface (Sci-Fi, Comedy, Horror, 1985)
41		Memoirs of an Invisible Man (Comedy, Romance, Sci-Fi, 1992)
40		Astronomy of Errors (Comedy, Romance, Sci-Fi, 2000)
40		Junior (Comedy, Romance, Sci-Fi, 1994)
40		Nutty Professor II: The Klumps (Comedy, Romance, Sci-Fi, 2000)
40		Multiplicity (Comedy, Romance, Sci-Fi, 1996)
40		Abbott and Costello Meet Dr. Jekyll and Mr. Hyde (Comedy, Horror, Mystery, Sci-Fi, 1953)
40		The Nutty Professor (Comedy, Romance, Sci-Fi, 1996)
40		Go and Get It (Comedy, Drama, Mystery, Sci-Fi, 1920)
40		Nosferatu vs. Father Pipecock & Sister Funk (Adventure, Comedy, Fantasy, Sci-Fi, 2014)
40		Codependent Lesbian Space Alien Seeks Same (Comedy, Romance, Sci-Fi, 2011)
40		The Mouse on the Moon (Comedy, Romance, Sci-Fi, 1963)
40		The Invisible Woman (Comedy, Romance, Sci-Fi, 1940)
40		I Heart Doomsday (Comedy, Romance, Sci-Fi, 2010)
40		My Super Ex-Girlfriend (Comedy, Romance, Sci-Fi, 2006)
40		The Nutty Professor (Comedy, Romance, Sci-Fi, 1963)
40		Poultrygeist: Night of the Chicken Dead (Comedy, Horror, Musical, Sci-Fi, 2006)
40		Fido (Comedy, Drama, Horror, Sci-Fi, 2006)
39		The Man with Nine Lives (Mystery, Sci-Fi, 1940)
39		Virtuosity (Action, Crime, Sci-Fi, 1995)
38		Cocoon (Sci-Fi, 1985)
37		World Without End (Adventure, Romance, Sci-Fi, 1956)
37		Spider Baby or, The Maddest Story Ever Told (Comedy, Horror, Sci-Fi, 1967)
37		John Dies at the End (Comedy, Horror, Sci-Fi, 2012)
37		Galaxy Quest (Adventure, Comedy, Sci-Fi, 1999)
36		About Time (Comedy, Drama, Fantasy, Sci-Fi, 2013)
36		Teenage Mutant Ninja Turtles II: The Secret of the Ooze (Action, Adventure, Comedy, Sci-Fi, 1991)
36		Waxwork II: Lost in Time (Comedy, Fantasy, Horror, Sci-Fi, 1992)
35		Critters 2 (Comedy, Horror, Sci-Fi, 1988)
35		The Adventures of Buckaroo Banzai Across the 8th Dimension (Adventure, Comedy, Romance, Sci-Fi, 1984)
35		Doctor X (Comedy, Crime, Horror, Sci-Fi, 1932)
35		The Silencers (Action, Adventure, Comedy, Sci-Fi, 1966)
35		Shank (Action, Comedy, Crime, Sci-Fi, 2010)
35		Munster, Go Home! (Comedy, Family, Fantasy, Sci-Fi, 1966)
35		Underworld: Evolution (Action, Adventure, Fantasy, Sci-Fi, 2006)
34		Universal Soldier: The Return (Action, Sci-Fi, 1999)
34		Crank: High Voltage (Action, Crime, Sci-Fi, 2009)
33		The Garden's Keeper (Action, Comedy, Sci-Fi, 2015)
33		Earth Girls Are Easy (Comedy, Musical, Romance, Sci-Fi, 1988)
33		Back to the Future (Adventure, Comedy, Sci-Fi, 1985)
32		Voyage of the Rock Aliens (Musical, Sci-Fi, Comedy, 1984)
32		Repo Man (Comedy, Crime, Sci-Fi, 1984)
32		What's Up, Hideous Sun Demon (Comedy, Sci-Fi, 1983)
32		Man with the Screaming Brain (Adventure, Comedy, Sci-Fi, 2005)
32		Nothing Lasts Forever (Comedy, Fantasy, Sci-Fi, 1984)
32		Starman (Romance, Sci-Fi, 1984)
32		Night of the Comet (Comedy, Horror, Sci-Fi, 1984)
32		Hyperspace (Sci-Fi, Comedy, 1984)
32		The Absent Minded Professor (Comedy, Family, Sci-Fi, 1961)
32		Big Meat Eater (Comedy, Musical, Sci-Fi, 1982)
32		Airplane II: The Sequel (Comedy, Sci-Fi, 1982)
32		I Was a Zombie for the F.B.I. (Comedy, Sci-Fi, 1982)
32		Illegal Alien (Comedy, Sci-Fi, 1982)
32		Jekyll and Hyde... Together Again (Sci-Fi, Comedy, Music, 1982)
32		Human Highway (Comedy, Drama, Sci-Fi, 1982)
32		Superman III (Action, Comedy, Sci-Fi, 1983)
32		Zapped! (Comedy, Fantasy, Sci-Fi, 1982)
32		Blood Suckers from Outer Space (Comedy, Horror, Sci-Fi, 1984)
32		The Brother from Another Planet (Comedy, Sci-Fi, 1984)
32		Xing ji dun tai (Sci-Fi, Comedy, 1983)
32		The Diamonds of Metro Valley (Action, Comedy, Sci-Fi, 2010)
32		Strangers in Paradise (Comedy, Musical, Sci-Fi, 1984)
31		Caveman (Comedy, Sci-Fi, 1981)
31		The Stuff (Comedy, Horror, Sci-Fi, 1985)
31		Earthbound (Family, Sci-Fi, Comedy, 1981)
31		Short Circuit (Comedy, Family, Sci-Fi, 1986)
31		The Incredible Shrinking Woman (Comedy, Sci-Fi, 1981)
31		Telling Tales (Comedy, Fantasy, Romance, Sci-Fi, 2015)
31		TerrorVision (Comedy, Horror, Sci-Fi, 1986)
31		The Revenge of the Teenage Vixens from Outer Space (Comedy, Sci-Fi, 1985)
31		UFOria (Comedy, Sci-Fi, 1985)
31		Fright Show (Horror, Comedy, Sci-Fi, 1985)
31		The Trouble with Dick (Comedy, Sci-Fi, 1986)
31		Modern Problems (Comedy, Fantasy, Sci-Fi, 1981)
31		Heartbeeps (Sci-Fi, Comedy, 1981)
31		The American Way (Comedy, Sci-Fi, 1986)
31		Nu ji xie ren (Action, Comedy, Crime, Sci-Fi, 1991)
31		Blood Beach (Comedy, Horror, Sci-Fi, 1980)
31		Class of Nuke 'Em High (Comedy, Horror, Sci-Fi, 1986)
31		Simon (Comedy, Sci-Fi, 1980)
31		Star Trek IV: The Voyage Home (Adventure, Comedy, Sci-Fi, 1986)
31		Monster in the Closet (Comedy, Horror, Sci-Fi, 1986)
31		Morons from Outer Space (Comedy, Sci-Fi, 1985)
30		Project X (Comedy, Drama, Sci-Fi, 1987)
30		Norman's Awesome Experience (Comedy, Sci-Fi, 1988)
30		Eat and Run (Comedy, Sci-Fi, 1987)
30		King Lear (Comedy, Drama, Sci-Fi, 1987)
30		Real Men (Action, Comedy, Sci-Fi, 1987)
30		Amazon Women on the Moon (Comedy, Sci-Fi, 1987)
30		Locke the Superman (Animation, Action, Romance, Sci-Fi, 1984)
30		Back to the Future Part II (Adventure, Comedy, Sci-Fi, 1989)
30		It Came from Somewhere Else (Comedy, Sci-Fi, 1988)
30		The Pink Chiquitas (Comedy, Horror, Sci-Fi, 1987)
30		Purple People Eater (Comedy, Family, Sci-Fi, 1988)
30		Spaceballs (Adventure, Comedy, Sci-Fi, 1987)
30		Where's Willie? (Comedy, Family, Sci-Fi, 1978)
30		Looney Tunes: Back in Action (Animation, Adventure, Comedy, Sci-Fi, 2003)
30		Teknolust (Comedy, Drama, Romance, Sci-Fi, 2002)
30		Pajama Party (Comedy, Musical, Romance, Sci-Fi, 1964)
30		Return of the Killer Tomatoes! (Comedy, Horror, Sci-Fi, 1988)
30		Zathura: A Space Adventure (Action, Adventure, Comedy, Sci-Fi, 2005)
30		Bubble Boy (Adventure, Comedy, Romance, Sci-Fi, 2001)
30		Virtual Sexuality (Comedy, Drama, Romance, Sci-Fi, 1999)
30		Akumulátor 1 (Comedy, Fantasy, Romance, Sci-Fi, 1994)
30		Highlander: The Final Dimension (Action, Fantasy, Romance, Sci-Fi, 1994)
30		I Married a Strange Person! (Animation, Comedy, Drama, Sci-Fi, 1997)
30		Blast from the Past (Comedy, Drama, Romance, Sci-Fi, 1999)
30		The Importance of Being Russell (Comedy, Fantasy, Romance, Sci-Fi, 2006)
30		Kaboom (Comedy, Mystery, Romance, Sci-Fi, 2010)
30		The Lobster (Comedy, Drama, Romance, Sci-Fi, 2015)
30		Home (Animation, Adventure, Comedy, Sci-Fi, 2015)
30		It Happened in New York (Comedy, Music, Romance, Sci-Fi, 1935)
30		Sons of Steel (Comedy, Musical, Sci-Fi, 1988)
30		Killer Klowns from Outer Space (Comedy, Horror, Sci-Fi, 1988)
30		Coyote (Comedy, Fantasy, Horror, Sci-Fi, 2014)
30		Comet (Comedy, Drama, Romance, Sci-Fi, 2014)
30		Griff the Invisible (Comedy, Drama, Romance, Sci-Fi, 2010)
30		The Future (Comedy, Drama, Romance, Sci-Fi, 2011)
30		Men in Black 3 (Action, Adventure, Comedy, Sci-Fi, 2012)
30		Earthbound (Comedy, Fantasy, Romance, Sci-Fi, 2012)
30		The Invisible Kid (Comedy, Sci-Fi, 1988)
30		Goodbye, 20th Century (Adventure, Comedy, Fantasy, Sci-Fi, 1998)
30		The Time Guardian (Action, Romance, Sci-Fi, 1987)
30		Very Close Encounters of the Fourth Kind (Comedy, Sci-Fi, 1978)
30		The Cat from Outer Space (Comedy, Family, Sci-Fi, 1978)
30		Spaced Out (Comedy, Sci-Fi, 1979)
30		Piranha (Comedy, Horror, Sci-Fi, 1978)
30		C.H.O.M.P.S. (Comedy, Family, Sci-Fi, 1979)
30		Hell Comes to Frogtown (Action, Comedy, Sci-Fi, 1988)
30		As Time Goes by (Comedy, Sci-Fi, 1988)
30		Bad Taste (Comedy, Horror, Sci-Fi, 1987)
30		Return of the Living Dead II (Comedy, Horror, Sci-Fi, 1988)
30		Interzone (Action, Comedy, Sci-Fi, 1987)
30		The Troops & Aliens (Comedy, Crime, Sci-Fi, 1979)
29		Second Sight (Comedy, Mystery, Sci-Fi, 1989)
29		Tremors (Comedy, Horror, Sci-Fi, 1990)
29		Meet the Applegates (Comedy, Sci-Fi, 1990)
29		Rocky Horror Show Live (Comedy, Musical, Sci-Fi, 2015)
29		Spaced Invaders (Adventure, Comedy, Sci-Fi, 1990)
29		TRON (Action, Adventure, Sci-Fi, 1982)
29		Anna to the Infinite Power (Sci-Fi, 1983)
29		Self/less (Action, Mystery, Sci-Fi, 2015)
29		The Age of Insects (Sci-Fi, Comedy, Horror, 1990)
29		The Spirit of '76 (Comedy, Sci-Fi, 1990)
29		Invasion: Stanford 1991 A.D. (Comedy, Sci-Fi, 1990)
29		The Return of Swamp Thing (Sci-Fi, Horror, Comedy, 1989)
29		Terminal City Ricochet (Comedy, Sci-Fi, 1990)
29		Buck Rogers (Romance, Sci-Fi, 1977)
29		Alien Space Avenger (Comedy, Horror, Sci-Fi, 1989)
29		The Truman Show (Comedy, Drama, Sci-Fi, 1998)
29		2076 Olympiad (Comedy, Sci-Fi, 1977)
29		Possible Worlds (Mystery, Sci-Fi, Crime, 2000)
29		Invasion (Sci-Fi, 1966)
29		Wooly Booly: Ang classmate kong alien (Comedy, Sci-Fi, 1989)
29		Meet the Hollowheads (Comedy, Horror, Sci-Fi, 1989)
29		Fantastic Voyage (Adventure, Family, Sci-Fi, 1966)
29		Rising Storm (Action, Comedy, Sci-Fi, 1989)
29		Mutant on the Bounty (Comedy, Sci-Fi, 1989)
29		Lobster Man from Mars (Comedy, Horror, Sci-Fi, 1989)
28		There's Nothing Out There (Comedy, Horror, Sci-Fi, 1991)
28		G.O.R.A. (Adventure, Comedy, Sci-Fi, 2004)
28		Space Case (Comedy, Sci-Fi, 1992)
28		Flytrap (Comedy, Drama, Sci-Fi, 2015)
28		Abby Sen (Comedy, Drama, Sci-Fi, 2015)
28		Le grand tout (Comedy, Drama, Sci-Fi, 2016)
28		Tribulation 99: Alien Anomalies Under America (Comedy, Sci-Fi, 1992)
28		Critters 4 (Comedy, Horror, Sci-Fi, 1992)
28		Class of Nuke 'Em High Part II: Subhumanoid Meltdown (Comedy, Horror, Sci-Fi, 1991)
28		The Borrower (Comedy, Horror, Sci-Fi, 1991)
28		Suburban Commando (Action, Comedy, Sci-Fi, 1991)
28		Critters 3 (Comedy, Horror, Sci-Fi, 1991)
28		Guyver (Sci-Fi, Action, Comedy, 1991)
28		Blobermouth (Comedy, Horror, Sci-Fi, 1991)
28		The Sexplorer (Comedy, Sci-Fi, 1975)
28		Death Race 2000 (Action, Comedy, Sci-Fi, 1975)
28		Flesh Gordon (Comedy, Sci-Fi, 1974)
28		Dark Star (Comedy, Sci-Fi, 1974)
28		The Time Machine (Adventure, Romance, Sci-Fi, 1960)
28		The Invisible Man (Comedy, Horror, Sci-Fi, 1933)
28		Planet of the Apes (Adventure, Romance, Sci-Fi, 1968)

Notes: Movies similar to The Man with Two Brains, Movies like The Man with Two Brains, Comedy, Romance, Sci-Fi, Carl Reiner, Steve Martin, Kathleen Turner, David Warner, Paul Benedict, SF, Science Fiction, SciFi, Sci Fi, Films, Video, Movie Similarities