70		Shades of Death: Royal Blood (Windows, 2011)
70		The Filmmaker (Windows, 2010)
64		Fran Bow (Windows, 2015)
64		Red Haze (Windows, 2017)
60		Lisa: The First (Windows, 2012)
55		Horns of Fear (Windows, 2018)
55		From Beyond: Prologue (Windows, 2018)
55		Please Love My Computer Game (Windows, 2018)
54		Trilby's Notes (Windows, 2006)
53		Ceasing to be her Demise (Windows, 2016)
52		Close Your Eyes (Windows, 2015)
51		Blackbay Asylum: Home for the Criminally Insane (Windows, 2014)
51		Sanitarium (Windows, 1998)
50		Psycho (DOS, 1988)
50		Echoes of Sorrow (Windows, 2011)
50		The Darkest Night (DOS, 1996)
50		rein (Windows, 2010)
50		Shiver: Vanishing Hitchhiker (Windows, 2011)
50		Sonya (Windows, 2012)
50		Twisted Lands: Insomniac (Windows, 2011)
47		Maggie's Apartment (Windows, 2017)
46		Viviette (Windows, 2018)
46		The Miskatonic (Windows, 2018)
46		Trick & Treat (Windows, 2016)
45		Lovecraft Quest: A Comix Game (Windows, 2018)
45		Franky the Bumwalker (Windows, 2018)
44		Stasis (Windows, 2015)
44		9 Clues 2: The Ward (Windows, 2015)
44		Humble Abode (Windows, 2017)
44		The Dagger of Amon Ra (Windows, 2017)
43		Streifen (Windows, 2016)
43		The Cat Lady (Windows, 2012)
43		Pocket Mirror (Windows, 2016)
43		Octave (Windows, 2016)
42		Wait: Extended (Windows, 2015)
42		Nevermind (Windows, 2015)
42		Being Her Darkest Friend (Windows, 2015)
42		Time Mysteries: Inheritance - Remastered (Windows, 2015)
41		Whispering Willows (Windows, 2014)
41		The Path (Windows, 2009)
40		The Dagger of Amon Ra (DOS, 1992)
40		D (DOS, 1996)
40		Jack in the Dark (DOS, 1993)
40		The Romantic Blue (DOS, 1994)
40		The Dark Convergence II (DOS, 1994)
40		The Dark Convergence (DOS, 1993)
40		Nightmare Adventures: The Witch's Prison (Windows, 2010)
40		Black Sect Remake (Windows, 2012)
40		The Lurking Horror (Windows, 2011)
40		Stranger by Night (Windows, 2004)
40		Abyss: The Wraiths of Eden (Windows, 2012)
40		Murder, She Wrote 2: Return to Cabot Cove (Windows, 2013)
40		The Experiment Part 2: Menacing Darkness (Windows, 2011)
40		Time Mysteries: Inheritance (Windows, 2010)
40		Clock Tower (Windows, 1997)
40		The Vampire Diaries (Windows, 1996)
40		Armed & Delirious (Windows, 1997)
40		Daria's Inferno (Windows, 2000)
40		A Vampire Romance (Windows, 2010)
40		The Path: Prologue (Windows, 2009)
40		Becky Brogan: The Mystery of Meane Manor (Windows, 2009)
40		Bloodline of the Fallen: Anna's Sacrifice (Windows, 2010)
40		D (Windows, 1995)
40		Campfire Legends: The Babysitter (Windows, 2010)
40		Haunted Halls: Green Hills Sanitarium (Windows, 2010)
40		The Rockin' Dead (Windows, 2011)
40		Escape from Frankenstein's Castle (Windows, 2010)
40		Vampire Brides: Love Over Death (Windows, 2010)
40		Campfire Legends: The Hookman (Windows, 2009)
40		3 Cards to Dead Time (Windows, 2010)
40		Immortal Lovers (Windows, 2010)
40		Nightfall Mysteries: Asylum Conspiracy (Windows, 2010)
40		Miserere (Windows, 2012)

Notes: Games similar to My Big Sister, Games like My Big Sister, Stranga, Grab The Games, Windows, Adventure, Graphic Adventure, Puzzle elements, Horror, Bird's-eye view, Fixed, Flip-screen, Female, PC, Game Similarities.