43		RedJack: The Revenge of the Brethren (Windows, 1998)
40		This is Infinity (Windows, 2009)
40		uin (Windows, 2010)
40		Spuds Quest (Windows, 2006)
40		Garfield (Windows, 2005)
40		Batman: Justice Unbalanced (Windows, 2003)
40		Batman: Toxic Chill (Windows, 2003)

Notes: Games similar to Marvel Comics Spider-Man: The Sinister Six, Games like Marvel Comics Spider-Man: The Sinister Six, Brooklyn Multimedia, Byron Preiss Multimedia Company, Inc., DOS, Action, Adventure, Fighting, Puzzle elements, 3rd-person, Other, Marvel, Spider-Man, PC, Game Similarities.