45		The Star Portal (DOS, 1988)
45		The Twilight Zone (DOS, 1988)
45		Star Trek: First Contact (DOS, 1988)
44		Timequest (DOS, 1991)
44		Stationfall (DOS, 1987)
44		Supernova (DOS, 1987)
43		Frederik Pohl's Gateway (DOS, 1992)
43		Star Trek: The Promethean Prophecy (DOS, 1986)
42		Demoniak (DOS, 1991)
42		Star Trek: The Kobayashi Alternative (DOS, 1985)
42		The Adventures of Buckaroo Banzai: Across the Eighth Dimension (DOS, 1985)
42		Projekt Prometheus (DOS, 1991)
42		Nine Princes in Amber (DOS, 1985)
42		Dopplegänger (DOS, 1985)
42		Rendezvous with Rama (DOS, 1985)
41		Gateway II: Homeworld (DOS, 1993)
41		Amazon (DOS, 1984)
40		Kingdom Without End (DOS, 2001)
40		Versus: The Elite Trials (Windows, 2016)
40		Las llaves del tiempo (DOS, 1999)
40		Alien (DOS, 1982)
40		Frederik Pohl's Gateway (Windows, 1995)
40		Planetfall (DOS, 1983)
40		Starcross (DOS, 1982)
40		Gun Mute (Windows, 2008)

Notes: Games similar to Guardians of Infinity: To Save Kennedy, Games like Guardians of Infinity: To Save Kennedy, Paragon Software Corporation, Paragon Software Corporation, DOS, Adventure, Sci-Fi, Futuristic, Interactive Fiction, Text Adventure, PC, Game Similarities.