99		The Binding of Isaac (Windows, 2011)
73		Nuclear Throne (Windows, 2013)
71		Wasteland Kings (Windows, 2013)
67		Geometry Wars 3: Dimensions - Evolved (Windows, 2014)
66		A Fistful of Gun (Windows, 2015)
65		Secret Ponchos (Windows, 2014)
64		Friendship Club (Windows, 2015)
63		Ghostbusters (Windows, 2016)
63		8DAYS (Windows, 2016)
63		Bombshell (Windows, 2016)
62		Atomine (Windows, 2017)
61		Alien Breed: Evolution - Episode 1 (Windows, 2010)
61		Leap of Fate (Windows, 2016)
54		Nex Machina (Windows, 2017)
53		Demon's Crystals (Windows, 2016)
53		All Zombies Must Die! (Windows, 2012)
52		Tower 57 (Windows, 2017)
51		Scalpers: Turtle & the Moonshine Gang (Windows, 2018)
51		Biology Battle (Windows, 2010)
45		BANG BANG BANG! (Windows, 2014)
45		Crimsonland (Windows, 2014)
44		A Goblin's Xmas Tale (Windows, 2015)
44		Rumble (Windows, 2015)
44		How to Survive (Windows, 2013)
44		How to Survive 2 (Windows, 2015)
43		Lost Sea (Windows, 2016)
43		Fresh Body (Windows, 2016)
43		Spareware (Windows, 2016)
43		Action Legion (Windows, 2016)
42		Yet Another Zombie Defense HD (Windows, 2017)
42		Freaky Awesome (Windows, 2017)
42		Genetic Disaster (Windows, 2017)
42		Rogue'n Roll (Windows, 2017)
42		Landfall (Windows, 2017)
41		Mini Battlegrounds (Windows, 2018)
41		I Hate Running Backwards (Windows, 2018)
41		Toon War (Windows, 2018)
41		Burn, Zombie Burn! (Windows, 2010)
41		Black Widow (Windows, 2010)
40		Dead Planet (Windows, 2008)
40		Monster Madness: Battle for Suburbia (Windows, 2007)
40		Heavy Barrel (DOS, 1989)
40		Llamatron: 2112 (DOS, 1992)
40		Adam the New Age Warrior in "Time After Time" (DOS, 1994)
40		Centipede (Windows, 1998)

Notes: Games similar to The Binding of Isaac: Rebirth, Games like The Binding of Isaac: Rebirth, Nicalis, Inc., Nicalis, Inc., Windows, Action, Roguelike, Shooter, Bird's-eye view, Dual, Twin-stick shooter, PC, Game Similarities.